Inflammatory Bowel Disease: Definition, Symptoms, Diagnosis, and Treatment

Question 1

Which histologic finding is characteristically seen in Crohn's disease?

Accepted Answer

Crypt abscesses

Answer

Villous atrophy

Answer

Diverticular formation

Answer

Intestinal pseudoobstruction

Question 2

The Montreal classification of inflammatory bowel disease categorizes disease location as:**

Accepted Answer

L, C, P

Answer

A, B, C

Answer

E, C, D

Answer

I, B, D

Question 3

The definitive diagnostic method for inflammatory bowel disease is:

Accepted Answer

Endoscopy with biopsy

Answer

Blood tests

Answer

Imaging studies

Answer

Patient history

Question 4

Which of the following medications is typically used as a first-line treatment for mild to moderate Crohn's disease?

Accepted Answer

5-aminosalicylic acid (5-ASA)

Answer

Budesonide

Answer

Methotrexate

Answer

Azathioprine

Question 5

Which surgical procedure is commonly performed to treat Crohn's disease affecting the ileocecal region?

Accepted Answer

Ileocecal resection

Answer

Colectomy

Answer

Proctocolectomy

Answer

Bowel resection

Question 6

What is a non-specific finding on histology that is common to both ulcerative colitis and Crohn's disease?

Accepted Answer

Lymphoid aggregates

Answer

Crypt abscesses

Answer

Non-caseating granulomas

Answer

Goblet cell depletion

Question 7

What diagnostic technique is considered the gold standard for confirming a diagnosis of inflammatory bowel disease (IBD)?

Accepted Answer

Colonoscopy with biopsy

Answer

Barium enema

Answer

Capsule endoscopy

Answer

MRI enterography

Question 8

Which medication is used as the first-line treatment for induction of remission in mild to moderate ulcerative colitis?

Accepted Answer

Mesalamine

Answer

Prednisone

Answer

Azathioprine

Answer

Infliximab

Question 9

What term describes the discontinuous involvement of the bowel wall in Crohn's disease?

Accepted Answer

Skip lesions

Answer

Segments

Answer

Stenosis

Answer

Fistulas

Question 10

Which clinical feature is characteristic of ulcerative colitis?

Accepted Answer

Bloody diarrhea

Answer

Perianal disease

Answer

Weight loss

Answer

Fever

Question 11

What medication is typically the first-line treatment for mild to moderate ulcerative colitis?

Accepted Answer

5-aminosalicylic acid

Answer

Corticosteroids

Answer

Immunomodulators

Answer

Biologics

Question 12

What is the general prognosis of IBD?

Accepted Answer

Highly variable depending on the specific type and severity of IBD

Answer

Usually curable

Answer

Generally favorable with reasonable quality of life

Answer

Often leads to severe complications

Question 13

Which of the following is NOT a characteristic endoscopic or histological finding in ulcerative colitis?

Accepted Answer

Skip lesions

Answer

Erythema

Answer

Friability

Question 14

Which of the following is NOT a type of inflammatory bowel disease (IBD)?

Accepted Answer

Cystic fibrosis

Answer

Ulcerative colitis

Answer

Crohn's disease

Answer

Microscopic colitis

Question 15

Which diagnostic test is most commonly used to confirm the diagnosis of IBD?

Accepted Answer

Colonoscopy

Answer

Upper endoscopy

Answer

Computed tomography (CT) scan

Answer

Magnetic resonance imaging (MRI)

Question 16

Which of the following is a first-line treatment for mild to moderate ulcerative colitis?

Accepted Answer

Aminosalicylates

Answer

Corticosteroids

Answer

Immunomodulators

Answer

Biologics

Question 17

Which of the following is a hallmark clinical feature of Crohn's disease?

Accepted Answer

Transmural inflammation that can involve any segment of the gastrointestinal tract

Answer

Mucosal inflammation confined to the colon and rectum

Answer

Perianal disease

Answer

Exclusive involvement of the stomach and esophagus

Question 18

Which diagnostic procedure is considered the gold standard for confirming inflammatory bowel disease?

Accepted Answer

Endoscopy with biopsy

Answer

Blood tests

Answer

Imaging studies

Answer

Physical examination

Question 19

Which medication is commonly used as first-line therapy for mild to moderate ulcerative colitis?

Accepted Answer

Mesalamine

Answer

Prednisone

Answer

Azathioprine

Answer

Infliximab

Question 20

What is the primary goal of fecal microbiota transplantation in the management of inflammatory bowel disease?

Accepted Answer

Restoring the balance of gut microbiota

Answer

Suppressing immune responses

Answer

Treating mucosal inflammation directly

Answer

Preventing disease recurrence

Question 21

Which of the following is NOT a type of inflammatory bowel disease (IBD)?

Accepted Answer

Irritable bowel syndrome (IBS)

Answer

Ulcerative colitis

Answer

Crohn's disease

Answer

Microscopic colitis

Question 22

What is the primary pathophysiologic mechanism of IBD?

Accepted Answer

Dysregulation of the immune response

Answer

Infectious agent

Answer

Genetic predisposition

Answer

Environmental factors

Question 23

Which of the following is a characteristic clinical presentation of ulcerative colitis?

Accepted Answer

Bloody diarrhea

Answer

Abdominal pain

Answer

Nausea and vomiting

Answer

Fever

Question 24

Which diagnostic tool is most commonly used to visualize the extent and severity of Crohn's disease?

Accepted Answer

Magnetic resonance enterography (MRE)

Answer

Colonoscopy

Answer

Upper endoscopy

Answer

Barium enema

Question 25

What is the first-line treatment for mild to moderate ulcerative colitis?

Accepted Answer

5-aminosalicylic acid (5-ASA)

Answer

Corticosteroids

Answer

Immunomodulators

Answer

Biologic therapy

Question 26

In the ethical management of inflammatory bowel disease, which principle is paramount?

Accepted Answer

Respecting patient autonomy and informed decision-making

Answer

Prioritizing cost-effective treatments

Answer

Adhering strictly to established treatment guidelines

Answer

Consulting with numerous specialists before determining a treatment plan

Question 27

Which of the following are common psychological and social challenges experienced by individuals with inflammatory bowel disease (IBD)?

Accepted Answer

Depression, anxiety, and social isolation

Answer

Weight gain, hair loss, and fatigue

Answer

Increased risk of cardiovascular disease and cancer

Question 28

Which of the following is a common symptom of Crohn's disease? Choose the best answer.

Accepted Answer

Abdominal pain affecting the right lower quadrant

Answer

Polyuria

Answer

Blurred vision

Answer

Weight gain

Question 29

Select the most common risk factor for developing ulcerative colitis.

Accepted Answer

Family history of the disease

Answer

Age over 65 years

Answer

Regular intake of non-steroidal anti-inflammatory drugs (NSAIDs)

Question 30

Which of the following medications is the mainstay of therapy for mild to moderate ulcerative colitis?

Accepted Answer

5-aminosalicylic acid (5-ASA)

Answer

Surgery

Answer

Immunomodulators, such as azathioprine

Answer

Biologic agents, such as infliximab

Question 31

Which of the following is an indication for surgery in Crohn's disease?

Accepted Answer

Development of an intestinal obstruction

Answer

Mild abdominal pain that does not respond to medical therapy

Answer

Inadequate response to antibiotic therapy

Question 32

Which of the following types of inflammatory bowel disease primarily affects the large intestine?

Accepted Answer

Ulcerative colitis

Answer

Crohn's disease

Answer

Diverticulitis

Answer

Microscopic colitis

Question 33

Identify the endoscopic finding characteristic of ulcerative colitis.

Accepted Answer

Mucosal friability and dễtachment with bleeding upon contact

Answer

Ulcers

Answer

Skip lesions

Answer

Cobblestone appearance

Question 34

In managing inflammatory bowel disease (IBD), which healthcare professionals are crucial members of the care team?

Accepted Answer

Gastroenterologist, Surgeon, Registered Dietitian

Answer

Pediatrician, Nurse, Pharmacist

Answer

Cardiologist, Pulmonologist, Dermatologist

Question 35

Which of the following novel therapeutic interventions for refractory IBD targets the JAK-STAT signaling pathway?

Accepted Answer

Tofacitinib

Answer

Ustekinumab

Answer

Vedolizumab

Answer

Natalizumab

Question 36

Which of the following is NOT a characteristic of ulcerative colitis?

Accepted Answer

Transmural inflammation

Answer

Bloody diarrhea

Answer

Rectal involvement

Answer

Mucosal inflammation

Question 37

What is the first-line treatment for mild to moderate Crohn's disease?

Accepted Answer

5-aminosalicylic acid (5-ASA)

Answer

Antibiotics

Answer

Immunomodulators

Answer

Corticosteroids

Question 38

Which of the following surgical procedures is most commonly performed for ulcerative colitis?

Accepted Answer

Colectomy with ileal pouch-anal anastomosis (IPAA)

Answer

Ileocecal resection

Answer

Subtotal colectomy

Answer

Strictureplasty

Question 39

Which of the following is a risk factor for developing IBD?

Accepted Answer

Smoking

Answer

Regular exercise

Answer

High fiber diet

Answer

Childhood obesity

Question 40

What is the goal of maintenance therapy in IBD?

Accepted Answer

To prevent relapse

Answer

To improve quality of life

Answer

To cure the disease

Answer

To induce remission

Question 41

Which of the following is NOT a characteristic of Crohn's disease?

Accepted Answer

Involves only the colon

Answer

Perianal disease

Answer

Transmural involvement

Answer

Skip lesions

Question 42

Which of the following is a modifiable risk factor for the development of IBD?

Accepted Answer

Smoking

Answer

High-fiber diet

Answer

Low socioeconomic status

Answer

Old age

Question 43

What is the recommended first-line pharmacotherapy for mild-to-moderate Crohn's disease?

Accepted Answer

5-aminosalicylic acid

Answer

Antibiotics

Answer

Corticosteroids

Answer

Immunomodulators

Question 44

Which of the following is NOT a potential complication of surgical intervention for IBD?

Accepted Answer

Dyslipidemia

Answer

Gastroesophageal reflux disease

Answer

Short bowel syndrome

Answer

Osteoporosis

Question 45

What is the primary function of fecal calprotectin in the diagnosis of IBD?

Accepted Answer

Non-invasive marker of intestinal inflammation

Answer

Specific for ulcerative colitis

Answer

Diagnostic for Crohn's disease

Answer

Predictive of disease severity

Question 46

Which feature is NOT characteristic of inflammatory bowel disease (IBD)?

Accepted Answer

Mesenteric lymphadenopathy

Answer

Mucosal ulceration

Answer

Transmural inflammation

Answer

Skip lesions

Question 47

Which of the following is considered a modifiable risk factor for developing IBD?

Accepted Answer

Smoking

Answer

High-fiber diet

Answer

Regular exercise

Question 48

Which symptom is a common clinical presentation of Crohn's disease?

Accepted Answer

Abdominal pain

Answer

Nocturia

Answer

Constipation

Answer

Hemorrhoids

Question 49

Which diagnostic test is considered the gold standard for confirming a diagnosis of IBD?

Accepted Answer

Colonoscopy with biopsy

Answer

Upper endoscopy

Answer

Barium enema

Answer

Complete blood count

Question 50

Which medication is a first-line treatment option for mild-to-moderate ulcerative colitis?

Accepted Answer

Mesalamine

Answer

Infliximab

Answer

Prednisone

Answer

Azathioprine

Question 51

Which of the following is a potential long-term complication of IBD?

Accepted Answer

Colon cancer

Answer

Pneumonia

Answer

Stroke

Answer

Myocardial infarction

Question 52

Which of the following is an example of an extraintestinal manifestation of IBD?

Accepted Answer

Ankylosing spondylitis

Answer

Diverticulitis

Answer

Cholecystitis

Answer

Appendicitis

Question 53

Which of the following is an emerging treatment option for IBD?

Accepted Answer

Fecal microbiota transplantation

Answer

Antibiotics

Answer

Antidepressants

Answer

Statins