Gastrointestinal Pathology Quizzes: Test Your Knowledge

Question 1

In chronic pancreatitis, which histological change is a hallmark feature?

Accepted Answer

Acinar atrophy

Answer

Hyperplastic gastric mucosa

Answer

Crypt abscesses

Answer

Granulomatous inflammation

Question 2

The most prevalent type of gastric malignancy is:

Accepted Answer

Adenocarcinoma

Answer

Squamous cell carcinoma

Answer

Lymphoma

Answer

Gastrointestinal stromal tumor

Question 3

The histological finding of "ground-glass" hepatocytes is characteristic of:

Accepted Answer

Non-alcoholic fatty liver disease (NAFLD)

Answer

Alcoholic hepatitis

Answer

Viral hepatitis

Answer

Cirrhosis

Question 4

The most common site for the development of colorectal cancer is the:

Accepted Answer

Rectum

Answer

Cecum

Answer

Sigmoid colon

Answer

Ascending colon

Question 5

The Whipple triad is a clinical presentation associated with:

Accepted Answer

Pancreatic cancer

Answer

Cholangiocarcinoma

Answer

Appendicitis

Answer

Diverticulitis

Question 6

Which type of liver tumor is most commonly encountered in clinical practice?

Accepted Answer

Hepatocellular carcinoma

Answer

Cholangiocarcinoma

Answer

Hepatoblastoma

Answer

Angiosarcoma

Question 7

Which of the following is the most prevalent esophageal cancer subtype?

Accepted Answer

Squamous cell carcinoma

Answer

Adenocarcinoma

Answer

Sarcoma

Answer

Lymphoma

Question 8

In Helicobacter pylori-associated gastritis, what is the predominant microscopic feature?

Accepted Answer

Lymphocytic infiltration

Answer

Neutrophilic infiltration

Answer

Eosinophilic infiltration

Answer

Plasma cell infiltration

Question 9

Which type of colitis is distinguished by the presence of coalescent ulcers?

Accepted Answer

Ulcerative colitis

Answer

Diverticular disease

Answer

Ischemic colitis

Answer

Radiation colitis

Question 10

In chronic hepatitis B infection, which histological type of hepatocellular carcinoma is commonly found?

Accepted Answer

Trabecular

Answer

Scirrhous

Answer

Fibrolamellar

Answer

Lymphoepithelioma-like

Question 11

Which liver tumor is considered benign?

Accepted Answer

Hepatocellular adenoma

Answer

Metastatic carcinoma

Answer

Cholangiocarcinoma

Answer

Hepatoblastoma

Question 12

The predominant histological type of gastric cancer is:

Accepted Answer

Adenocarcinoma

Answer

Squamous cell carcinoma

Answer

Gastrointestinal stromal tumor

Answer

Lymphoma

Question 13

Which of the following factors is NOT considered a risk factor for developing colorectal cancer?

Accepted Answer

High intake of fruits and vegetables

Answer

Age over 50 years

Answer

Family history of colorectal cancer

Answer

Obesity

Question 14

Which diagnostic approach is considered the gold standard for confirming a diagnosis of Crohn's disease?

Accepted Answer

Endoscopic examination with biopsy

Answer

Blood test

Answer

Imaging study

Answer

Physical examination alone

Question 15

Which of the following is a characteristic microscopic feature of ulcerative colitis?

Accepted Answer

Mucosal ulceration and crypt distortion

Answer

Presence of granulomas and skip lesions

Answer

Transmural inflammation and fistulae

Answer

Pseudomembranes and neutrophilic infiltration

Question 16

Villous atrophy and crypt hyperplasia in the small intestine are characteristic of which condition?

Accepted Answer

Celiac disease

Answer

Crohn's disease

Answer

Ulcerative colitis

Answer

Microscopic colitis

Question 17

Which of the following is NOT a potential complication of acute pancreatitis?

Accepted Answer

Hepatic encephalopathy

Answer

Pseudocyst formation

Answer

Necrosis

Answer

Perforation

Question 18

Which of the following is the most common cause of cholestasis?

Accepted Answer

Bile duct obstruction

Answer

Hepatitis

Answer

Cirrhosis

Answer

Autoimmune disease

Question 19

What endoscopic finding is most characteristic of Crohn's disease in the small intestine?

Accepted Answer

Cobblestone mucosa

Answer

Friable mucosa

Answer

Thickened mucosal folds

Answer

Polypoid lesions

Question 20

Which histological feature is uniquely characteristic of chronic hepatitis B infection?

Accepted Answer

Ground-glass hepatocytes

Answer

Mallory-Denk bodies

Answer

Cirrhosis

Question 21

In colorectal cancer, which genetic mutations are commonly implicated?

Accepted Answer

TP53 and KRAS

Accepted Answer

APC

Answer

BRCA1

Question 22

In gastric adenocarcinoma diagnosis, which histological classification system is most commonly used to describe the distinct histological patterns?

Accepted Answer

Laurén classification system

Answer

TNM staging system

Answer

WHO classification system

Question 23

What is the pathognomonic microscopic finding in ulcerative colitis?

Accepted Answer

Cryptitis and crypt abscesses

Answer

Lymphocytic infiltrate in the lamina propria

Answer

Neutrophilic infiltrate in the submucosa

Answer

Granulomas

Question 24

Which type of gastric cancer is the most frequently diagnosed?

Accepted Answer

Adenocarcinoma

Answer

Squamous cell carcinoma

Answer

Lymphoma

Answer

Carcinoid tumor

Question 25

What is the characteristic histological finding associated with Helicobacter pylori infection?

Accepted Answer

Lymphocytic gastritis

Answer

Neutrophilic infiltrate in the gastric mucosa

Answer

Intestinal metaplasia

Answer

Paneth cell metaplasia

Question 26

Which neurological complication is most commonly seen in patients with advanced cirrhosis?

Accepted Answer

Hepatic encephalopathy

Answer

Stroke

Answer

Parkinsonism

Answer

Multiple sclerosis

Question 27

What is the typical endoscopic appearance of esophageal varices?

Accepted Answer

Raised, swollen, twisted veins

Answer

Flat, red lesions

Answer

Ulcerated lesions

Answer

White, raised plaques

Question 28

A 55-year-old woman with a history of Crohn's disease presents with a perirectal abscess. Which of the following is the most appropriate management for this complication?

Accepted Answer

Incision and drainage

Answer

Conservative management with pain medication

Answer

Antibiotics alone

Answer

Colectomy

Question 29

Predominantly which histological type accounts for the majority of gastric cancers?

Accepted Answer

Adenocarcinoma

Answer

Lymphoma

Answer

Carcinoid tumor

Answer

Squamous cell carcinoma

Question 30

A characteristic histological feature of Crohn's disease is:

Accepted Answer

Transmural inflammation with skip lesions

Answer

Appendicitis with neutrophilic infiltrate

Answer

Ulcerative colitis with crypt abscesses

Answer

Diverticular disease with pseudopolyps

Question 31

Which complication may arise as a potential sequela of acute pancreatitis?

Accepted Answer

Pseudocyst formation

Answer

Esophageal variceal bleeding

Answer

Pulmonary embolism

Answer

Colon perforation

Question 32

Which of the following is a well-established risk factor for the development of colorectal cancer?

Accepted Answer

Inflammatory bowel disease

Answer

Gastric ulcer

Answer

Appendicitis

Answer

Diverticular disease

Question 33

The histological hallmark of celiac disease is:

Accepted Answer

Villous atrophy with crypt hyperplasia

Answer

Paneth cell metaplasia

Answer

Crypt abscesses

Answer

Lymphoid aggregates

Question 34

Which histological finding is commonly observed in cases of acute appendicitis?

Accepted Answer

Neutrophilic infiltrate with mucosal ulceration

Answer

Lymphoid aggregates with germinal centers

Answer

Granulomatous inflammation with caseation

Answer

Eosinophilic infiltrate with crypt abscesses

Question 35

Mallory bodies and steatosis are histological hallmarks characteristically seen in:

Accepted Answer

Alcoholic liver disease

Answer

Lymphocytic hepatitis

Answer

Cirrhosis

Answer

Non-alcoholic fatty liver disease

Question 36

Which of the following histologic features is NOT characteristic of gastric adenocarcinoma?

Accepted Answer

Squamous cell differentiation

Answer

Lymphocytic infiltration

Answer

Intestinal metaplasia

Answer

Signet ring cells

Question 37

Which of the following is a well-established risk factor for inflammatory bowel disease?

Accepted Answer

Smoking

Answer

Vitamin D deficiency

Answer

High-fat diet

Answer

Low fiber intake

Question 38

The endoscopic finding of continuous mucosal ulceration is characteristic of which gastrointestinal disease?

Accepted Answer

Ulcerative colitis

Answer

Celiac disease

Answer

Crohn's disease

Question 39

Which of the following is the most prevalent cause of acute pancreatitis in adults?

Accepted Answer

Gallstones

Answer

Alcohol abuse

Answer

Hypertriglyceridemia

Answer

Idiopathic

Question 40

The histological hallmark of primary sclerosing cholangitis is:

Accepted Answer

Concentric fibrosis of interlobular bile ducts

Answer

Neutrophilic infiltration of the biliary epithelium

Answer

Lymphocytic infiltration of the portal tracts

Answer

Granulomatous inflammation

Question 41

Which of the following is a classic symptom of peptic ulcer disease?

Accepted Answer

Epigastric pain

Answer

Jaundice

Answer

Dysphagia

Answer

Ascites

Question 42

Which of the following is a malignant tumor of the pancreas?

Accepted Answer

Pancreatic ductal adenocarcinoma

Answer

Islet cell tumor

Answer

Chronic pancreatitis

Answer

Pancreatitis pseudocyst

Question 43

The presence of which of the following substances in the stool is indicative of gastrointestinal bleeding?

Accepted Answer

Hemoccult

Answer

Fecal fat

Answer

Reducing substances

Question 44

Which of the following is a common cause of acute pancreatitis?

Accepted Answer

Gallstones

Answer

Cirrhosis

Answer

Ulcerative colitis

Answer

Hemochromatosis

Question 45

Which of the following gross findings is characteristic of gastric adenocarcinoma?

Accepted Answer

Linitis plastica

Answer

Polypoid growth

Answer

Ulceration

Answer

Mucosal thickening

Question 46

Which of the following is a characteristic of ulcerative colitis?

Accepted Answer

Continuous mucosal involvement

Answer

Granulomatous inflammation

Answer

Skip lesions

Answer

Transmural inflammation